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Exchange 2013 Sending email from an application or Outlook POP

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Fairly new to Exchange and completely new to Exchange 2013. Migrated from External 3rd party POP mail to internal Exchange server. New Server2012 running Exchange2013standard. All Outlook accounts have been migrated to Exchange and can send/rcv ok. Have some applications that have email accounts for sending and trying to setup. Have been testing setup using Symantec Backup Exec 2012 email notifications. Test from application says that message is queued but it never arrives. I can login to OWA for the account being used and it sends properly. Have tried to setup in Outlook as a POP3 account but getting server refused connection errors. Checked Services and both the POP3 and POP3 Backend services were off/manual. Started both and changed to auto but same problem exists. Suspect that inability to login to exchange server using POP3 in Outlook is same underlying problem with why application won't send. Suggestions or KB articles greatly appreciated.

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