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Delayed Email - Stuck in Queue

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Dears,

we have urgent issue all email form internal and external stayed in the Queue for one hour then delivered for the users

this below error i found in the queue in error message tab

"Last Error"
"mailbox database xxxxxxxxxx" "SMTP Delivery to Mailbox" Connecting 16  "[{LRT=6/1/2015 11:11:43 AM};{LED=441 4.4.1 Error encountered while communicating with primary target IP address: ""Failed to connect. Winsock error code: 10060, Win32 error code: 10060."" Attempted failover to alternate host, but that did not succeed. Either there are no alternate hosts, or delivery failed to all alternate hosts. The last endpoint attempted was xx.xx.xx.xx:475};{FQDN=mailbox database xxxxxxxxx};{IP=xx.xx.xx.xx}]"

Please Help Me really its a urgent issue


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